The fourth round of the FA Cup draw was conducted on Monday, and Nigeria duo Wilfred Ndidi and Kelechi Ihencho with their Leicester City teammates will face Championship side Brentford with the first leg taking place at the Griffin Park.
The Foxes defeated Wigan Athletic 2-0 in the third round fixture at the King Power Stadium.
Meanwhile, holders Manchester City will face Fulham at the Etihad Stadium.
With a number of replays still to be played, the Premier League’s biggest teams have been kept apart following an enthralling third round.
Liverpool will travel to Bristol City or Shrewsbury, while Manchester United and Tottenham still have replays to negotiate after third-round draws.
The fourth-round fixtures will take place between Friday, January 24 and Monday, January 27 once the final 32 teams have been confirmed.
Newcastle and Watford are the other Premier League teams held to replays by lower-league opposition.